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CAS: N/A
Chemical Name: PROTAC 23; 2-(2,6-Dioxopiperidin-3-yl)-5-(4-(2-(1-(4-(4-((1s,4s)-4-((5-isopropylpyrrolo[2,1-f][1,2,4]triazin-4-yl)amino)cyclohexyl)piperazin-1-yl)-4-oxobutanoyl)piperidin-4-yl)ethyl)piperazin-1-yl)isoindoline-1,3-dione
Purity: >98% (HPLC)
Novel potent and selective degrader of IRAK3, inducing proteasome-dependent degradation of IRAK3 and showing both CRBN and IRAK3 binding for activity
Ref: https://pubs.acs.org/doi/10.1021/acs.jmedchem.0c01125
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