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CAS: N/A
Chemical Name: (S)-N1-((2S,5R,8S,20S)-28-((2S,5R,8S,11S,14R,17S,20R)-5-benzyl-11,14,17,20-tetrakis(3-guanidinopropyl)-8-(naphthalen-2-ylmethyl)-3,6,9,12,15,18,21-heptaoxo-1,4,7,10,13,16,19-heptaazacyclohenicosan-2-yl)-20-carbamoyl-8-(hydroxymethyl)-1-(1H-imidazol-4-yl)-5-isobutyl-3,6,9,18,26-pentaoxo-13,16-dioxa-4,7,10,19,25-pentaazaoctacosan-2-yl)-2-((3S,6S,9S,12S,15S)-6,12-di((S)-sec-butyl)-3-(tert-butyl)-1-(2,3-dichloropyridin-4-yl)-15-((R)-1-hydroxyethyl)-9-(2-hydroxypropan-2-yl)-1,4,7,10,13-pentaoxo-2,5,8,11,14-pentaazahexadecan-16-amido)pentanediamide
Purity: >98% (HPLC)
Novel potent and selective blocker of the calcineurin-NFAT interaction (KD=16nM), preventing acute lung injury, being a promising novel treatment for ARDS and other inflammatory diseases
Ref: https://pubs.acs.org/doi/10.1021/acs.jmedchem.0c01236
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