Glixx Laboratories Inc
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Glixx Laboratorie
CAS: N/A
Chemical Name: Felix Kopp Kortagere 6; 1-(1-(Phenylsulfonyl)-1H-indol-2-yl)-1-(pyridin-4-yl)but-3-yn-1-ol
Purity: >98% (HPLC)
First-in-class non-cytotoxic pregnane X receptor (PXR) agonist, binding directly to PXR protein in solution, inducing PXR-specific target gene expression in cells, human organoids, and mice, significantly repressing pro-inflammatory cytokine production cells and abrogates inflammation in mice expressing the human PXR gene
References:
1) https://www.sciencedirect.com/science/article/abs/pii/S0045206821000377
2) https://www.embopress.org/doi/full/10.15252/emmm.201911621
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