Glixx Laboratories Inc
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Glixx Laboratorie
CAS: 2170137-61-6
Chemical Name: 2-((6-(4-Aminopiperidin-1-yl)-3,5-dicyano-4-ethylpyridin-2-yl)thio)-2-phenylacetamide
Purity: >98% (HPLC)
First-in-class potent, non-nucleoside, reversible, DNMT1-selective inhibitor (IC50: 0.17 µM), exerting robust DNA hypomethylation and gene activation, potently inhibiting growth of cancer cell lines, displaying improved tolerability and greater DNA hypomethylation than decitabine (DAC), translating into superior antitumour activity in models of AML.
References:
1) https://www.nature.com/articles/d41573-021-00171-y
2) https://www.nature.com/articles/s43018-021-00249-x
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