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Pol I Inhibitor T5

 

CAS: N/A

 

Chemical Name: 4-((3-(1-((((2S,3R,4R,5S,6R)-3,4-Dihydroxy-6-(hydroxymethyl)-5-(((2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2-yl)oxy)methyl)-1H-1,2,3-triazol-4-yl)propyl)amino)-2,7-bis(3-(dimethylamino)propyl)benzo[lmn][3,8]phenanthroline-1,3,6,8(2H,7H)-tetraone bis-TFA salt

 

 
GLXC-25130For Lab R&D Uses Only
        Cat No: GLXC-25130

 

Purity:               >95% (HPLC)

Storage:             Refrigerator (4 °C)

 

 

Product Description:

Novel RNA polymerase I inhibitor, targeting ribosomal DNA G-quadruplexes, potently and selectively inhibiting cell growth by high-affinity binding to G4s in ribosomal DNA, impairing RNA polymerase I (Pol I) elongation, inducing a rapid inhibition of Pol I transcription, nucleolus disruption, proteasome-dependent Pol I catalytic subunit A degradation and autophagy

 

Ref: https://www.cell.com/cell-chemical-biology/fulltext/S2451-9456(21)00266-X

 

Analytical data click for PDF file

 

 

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