Glixx Laboratories Inc
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Glixx Laboratorie
CAS: 2768472-28-0
Chemical Name: (2S,4R)-1-((S)-2-(8-(4-(4-((9-((S)-1-Acryloylpiperidin-3-yl)-8-(phenylamino)-9H-purin-2-yl)amino)phenyl)piperazin-1-yl)octanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide
Purity: >98% (HPLC)
Novel highly potent degrader against EGFRL858R/T790M and EGFRdel19, reaching the lowest DC50 values among all reported EGFR-targeting PROTACs
Ref: https://pubs.acs.org/doi/10.1021/acs.jmedchem.1c01827
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