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CAS: N/A
Chemical Name: SeThrRS-IN-36j; (2S,3R)-2-Amino-N-((R)-2-(3-(6,7-dichloro-4-oxoquinazolin-3(4H)-yl)propanamido)-1-(3-(1-oxoisoindolin-5-yl)phenyl)ethyl)-3-hydroxybutanamide
Purity: >98% (HPLC)
The first-in-class triple-site aaRS inhibitor, targeting Salmonella enterica threonyl-tRNA synthetase (SeThrRS) with IC50 = 19 nM and Kd = 35.4 nM
Ref: https://pubs.acs.org/doi/10.1021/acs.jmedchem.2c00134
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