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CAS: 2370013-49-1
Chemical Name: (S)-DZD9008; N-[5-[[4-[5-Chloro-4-fluoro-2-(2-hydroxypropan-2-yl)anilino]pyrimidin-2-yl]amino]-2-[(3S)-3-(dimethylamino)pyrrolidin-1-yl]-4-methoxyphenyl]prop-2-enamide
Purity: >98% (HPLC)
The S-enantiomer of Sunvozertinib, showing 51.2 nM, 51.9 nM, 1 nM, and 21.2 nM against EGFR exon 20 NPH and ASV insertions, EGFR L858R/T790M mutation and Her2 exon20 YVMA insertion, respectively, also inhibiting BTK
References:
1) https://www.tandfonline.com/doi/abs/10.1080/03007995.2022.2083326
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