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CAS: 3040999-70-7
Chemical Name: N-(trans-4-((5-Chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)cyclohexyl)acetamide
For Lab R&D Uses Only
Purity: >98% (HPLC)
Novel potent CDK7 inhibitor (IC50 = 7.21 nM), demonstrating a remarkable selectivity profile against a panel of kinases, including seven CDK subtypes, effectively inhibiting the phosphorylation of RNA polymerase II and CDK2 and resulted in G1/S phase cell cycle arrest and apoptosis in MV4-11 cells
Reference:
https://pubs.acs.org/doi/10.1021/acsmedchemlett.4c00040
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