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ROS1 degrader 9o

 

CAS: N/A

 

Chemical Name: 3-(5-(4-((4-(1-(4-((5-Chloro-4-((2-(dimethylphosphoryl)phenyl)amino)pyrimidin-2-yl)amino)-3-methoxyphenyl)piperidin-4-yl)piperazin-1-yl)methyl)piperidin-1-yl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione

 

 
GLXC-28975For Lab R&D Uses Only
        Cat No: GLXC-28975

 

Purity:               >98% (HPLC)

Storage:             Refrigerator (4 °C)

 

 

Product Description:

NNovel potent, orally active ROS1 degrader against CD74-ROS1 and the G2032R mutant, being effective against mutants that are resistant to repotrectinib, not only overcoming mutational resistance to currently approved ROS1 inhibitors but also addressing the vulnerability of next generation inhibitors that are not effective against certain on-target mutations such as L2098F and related combinations

 

Reference:

https://pubs.acs.org/doi/10.1021/acs.jmedchem.4c01205

 

Analytical data click for PDF file

 

 

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