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NCOA4 degrader V3

 

CAS: N/A

 

Chemical Name: N1-((R)-1-((2S,4R)-4-Hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)-N5-(2-(2-(2-(2-((2-(3-(6-(4-methylpiperazin-1-yl)-1H-benzo[d]imidazol-2-yl)phenyl)-1,2,3,4-tetrahydroisoquinolin-6-yl)oxy)ethoxy)ethoxy)ethoxy)ethyl)glutaramide

 

 
GLXC-28823For Lab R&D Uses Only
        Cat No: GLXC-28823

 

Purity:               >98% (HPLC)

Storage:             Refrigerator (4 °C)

 

 

Product Description:

Novel potent ferroptosis inhibitor with an intracellular ferrous iron inhibition mechanism, significantly reducing NCOA4 levels and downregulating intracellular ferrous iron (Fe2+) levels, thereby effectively suppressing ferroptosis induced by multiple pathways within cells and alleviating liver damage

 

Reference:

https://pubs.acs.org/doi/10.1021/acs.jmedchem.4c00403

 

Analytical data click for PDF file

 

 

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