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CAS: 2771246-13-8
Chemical Name: LY3537982; 4-((4aS)-3-Acryloyl-8-chloro-10-fluoro-12-oxo-2,3,4,4a,5,6-hexahydro-1H,12H-benzo[b]pyrazino[1,2-e][1,5]oxazocin-9-yl)-2-amino-7-fluorobenzo[b]thiophene-3-carbonitrile
For Lab R&D Uses Only
Purity: >98% (HPLC)
Next-generation covalent KRAS G12C inhibitor, reducing RAS activity and pERK levels, leading to substantial and significant tumor growth inhibition. Additionally, its combinations with immune checkpoint inhibitors demonstrates greater anti-tumor activity compared to monotherapy
References:
https://pubmed.ncbi.nlm.nih.gov/?term=Olomorasib&sort=date
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