Glixx Laboratories Inc
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Glixx Laboratorie
CAS: 303196-31-8
Chemical Name: 5-(2-Chlorophenyl)-1,2-dihydro-7-methoxy-3-methyl-pyrazolo[3,4-b][1,4]benzodiazepine
Cat No: GLXC-04699
For Lab R&D Uses Only
Purity: > 98% (HPLC)
Storage: Refrigerator (4 °C)
Potent inhibitor of cyclin-dependent kinase 2 (CDK2), well-tolerated and orally active for hepatocellular carcinoma and gastric cancer treatment via targeting angiogenesis and mitosis pathways, also showing IC50s 25±6, 67±4, 167±13 nM against VEGFR2, Aurora kinase A and B, respectively
References:
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0065264
https://www.sciencedirect.com/science/article/abs/pii/S0960894X10012151
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