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CAS: 2245237-53-8
Chemical Name: 6-Chloro-1-(4-fluoro-3,5-dimethylbenzyl)-4-(4-methylpiperazin-1-yl)-2-(2,6-diazaspiro[3.3]heptan-2-yl)-1H-benzo[d]imidazole
Purity: >98% (HPLC)
Novel SOS1 agonist, activating SOS1-Mediated Nucleotide Exchange on RAS. binding to SOS1 with low double-digit nanomolar affinity, rapidly enhancing cellular RAS-GTP levels, and invoking biphasic signaling changes in phosphorylation of ERK 1/2
Ref: https://pubs.acs.org/doi/10.1021/acs.jmedchem.8b01108
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