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CAS: 2195411-63-1
Chemical Name: Dimethyl shikonin oxime 5a; 1-((5E,8E)-5,8-Bis(hydroxyimino)-1,4-dimethoxy-5,8-dihydronaphthalen-2-yl)-2,2-dimethylbut-3-en-1-yl furan-2-carboxylate
Purity: >98% (HPLC)
Novel potent agonist for bombesin receptor subtype-3 (BB3, BRS-3) (pEC50 = 8.422 in IP-1 accumulation), being 898-fold more potent than DMAKO-00, improving glucose tolerance in C57BL/6 mice through BB3 and ameliorated glucose homeostasis in diabetic db/db mice without brain penetration
Reference:
https://pubs.acs.org/doi/10.1021/acs.jmedchem.3c00323
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