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CAS: 1807320-40-6
Chemical Name: 2-(4-(2-(2-(Benzylamino)ethoxy)ethoxy)phenyl)-4H-chromen-4-one
Purity: >98% (HPLC)
Novel potent P-glycoprotein (P-gp) inhibitor (EC50 = 83 nM), interacting with Q1193 and I1115 in the nucleotide-binding domain 2 (NBD2) of human P-gp, disrupting the R262-Q1081-Q1118 interaction pocket and uncoupling ICL2-NBD2 interaction and thereby inhibiting P-gp
References:
https://pubs.acs.org/doi/10.1021/acs.jmedchem.2c02005
https://www.mdpi.com/1422-0067/23/23/15299
Analytical data
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