Glixx Laboratories Inc
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Glixx Laboratorie
CAS: 2666951-70-6
Chemical Name: (2S,4R)-N-((S)-3-(4-((4-(((1r,3r)-3-(3-Chloro-4-cyanophenoxy)-2,2,4,4-tetramethylcyclobutyl)carbamoyl)phenyl)ethynyl)piperidin-1-yl)-3-oxo-1-phenylpropyl)-4-hydroxy-1-((R)-3-methyl-2-(3-methylisoxazol-5-yl)butanoyl)pyrrolidine-2-carboxamide
Purity: >98% (HPLC)
Novel highly potent proteolysis targeting chimera (PROTAC) AR degrader, effectively inducing degradation of AR protein in AR-positive (AR+) LNCaP, VCaP, and 22Rv1 prostate cancer cell lines with DC50 values of 0.2-1 nM
https://pubs.acs.org/doi/10.1021/acs.jmedchem.9b01393
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