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CAS: N/A
Chemical Name: N1-(3-(4-Amino-3-(1-(2-(3-(trifluoromethoxy)phenyl)acetyl)indolin-5-yl)-1H-indol-1-yl)propyl)-N12-((S)-1-((2R,4S)-4-hydroxy-2-(((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)dodecanediamide
Purity: >98% (HPLC)
First-in-class highly potent and specific RIPK1 degrader, potently inducing RIPK1 degradation with high specificity and substantially sensitizes multiple preclinical cancer models to anti-PD1 therapy
Reference:
https://www.biorxiv.org/content/10.1101/2024.03.25.586133v1.full
Analytical data
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