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CAS: N/A
Chemical Name: 4-((9-Chloro-7-(2-fluoro-6-methoxyphenyl)-5H-benzo[c]pyrimido[4,5-e]azepin-2-yl)methyl)-N-(5-((5-(4-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)phenoxy)pentyl)oxy)pentyl)-2-methoxybenzamide
For Lab R&D Uses Only
Purity: >98% (HPLC)
Second-generation alisertib-derived Aurora A PROTAC, exhibiting superior activity as a degrader in the HiBiT assay, Western blot analysis, and proteomics profiling compared to JB170
Reference:
https://pubs.acs.org/doi/10.1021/acs.jmedchem.5c03024
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