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CAS: 2087490-46-6
Chemical Name: (7R,10aR)-1-(4-((6-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)hexanamido)methyl)phenyl)-4-methyl-3,5,6,7,8,9,10,10a-octahydrocycloocta[d]pyridazin-7-yl (4-(4-((4-((2-acrylamidophenyl)amino)-5-chloropyrimidin-2-yl)amino)pyridin-2-yl)but-3-yn-1-yl)carbamate
Purity: >98% (HPLC)
Novel degrader of ERK1/2, eliciting downregulation of phospho-ERK1/2 signal
References:
https://www.cell.com/cell-chemical-biology/pdf/S2451-9456(17)30392-6.pdf
https://pubs.acs.org/doi/10.1021/acscentsci.6b00280
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