For Lab R&D Uses Only

Purity:               >98% (HPLC)

Product Description:

Potent and wild-type-sparing fourth-generation EGFR inhibitor for treatment of osimertinib-resistance NSCLC, potently inhibiting the EGFR^{L858R/T790M/C797S} mutant with an IC₅₀ value of 14 nM and suppressing the proliferation of H1975-TM cells with an IC₅₀ value of 14 nM, which show over 500-fold selectivity against wild-type forms, also inhibiting the EGFR^{del19/T790M/C797S} mutant and the proliferation of the PC9-TM cell line with IC₅₀ values of 62 and 82 nM

Reference:

https://pubs.acs.org/doi/10.1021/acs.jmedchem.3c00277

Analytical data

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