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CPP-SA-PTX

 

CAS: N/A

 

Chemical Name: 2-((2R,8S,11S,14S,17S,20S)-11-(4-Aminobutyl)-20-(4-(4-(((1S,2R)-1-benzamido-3-(((2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-diacetoxy-12-(benzoyloxy)-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxet-9-yl)oxy)-3-oxo-1-phenylpropan-2-yl)oxy)-4-oxobutanamido)butyl)-8-(3-guanidinopropyl)-17-isobutyl-14-methyl-3,6,9,12,15,18,21-heptaoxo-1,4,7,10,13,16,19-heptaazacyclohenicosan-2-yl)acetic acid

 

 
GLXC-27449For Lab R&D Uses Only
        Cat No: GLXC-27449

 

Purity:               >98% (HPLC)

Storage:             Refrigerator (4 °C)

 

 

Product Description:

Novel peptide-drug conjugate (PDC) as a pH-cleavable linker moiety, retaining pharmacological properties of paclitaxel (PTX) on positive β-tubulin-III, exhibiting the excellent solubility, enhanced stability (~90%) and cytotoxicity (EC50 = 8.32 ± 0.09 nM)

 

Reference:

https://pubs.acs.org/doi/10.1021/acs.jmedchem.3c00382


Analytical data click for PDF file

 

 

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