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CAS: N/A
Chemical Name: (2S,4R)-N-((S)-3-((11-(4-(3-((4-((3-Chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)propyl)piperazin-1-yl)-11-oxoundecyl)amino)-1-(4-(4-methylthiazol-5-yl)phenyl)-3-oxopropyl)-4-hydroxy-1-((R)-3-methyl-2-(3-methylisoxazol-5-yl)butanoyl)pyrrolidine-2-carboxamide
Purity: >98% (HPLC)
Novel EGFR degrader, selectively degrading the mutant but not the WT EGFR through both ubiquitination/proteasome and autophagy/lysosome pathways
Ref: https://pubs.acs.org/doi/10.1021/acs.jmedchem.2c00345
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