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CAS: N/A
Chemical Name: PL-SNS-032 conjugate 955; (E)-N-(5-(((5-(tert-Butyl)oxazol-2-yl)methyl)thio)thiazol-2-yl)-1-(2-(4-(2-(2,6-dimethoxy-4-(3-oxo-3-(6-oxo-3,6-dihydropyridin-1(2H)-yl)prop-1-en-1-yl)phenoxy)ethyl)piperazin-1-yl)-2-oxoethyl)piperidine-4-carboxamide
Purity: >98% (HPLC)
Novel CDK9 degrader, potently degrading CDK9 in a ubiquitin-proteasome-dependent manner and being much more potent than SNS-032 against various tumor cells in vitro, recruiting KEAP1 via covalent binding
Reference:
https://www.cell.com/cell-chemical-biology/fulltext/S2451-9456(23)00027-2
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