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CAS: 2416418-11-4
Chemical Name: 1-((3R,4R)-3-(4-(Pyridin-3-yl)-1H-1,2,3-triazol-1-yl)-4-((4-(trifluoromethyl)benzyl)oxy)pyrrolidin-1-yl)prop-2-en-1-one
For Lab R&D Uses Only
Purity: >98% (HPLC)
Novel irreversible TEAD inhibitor, binding with TEAD palmitate pocket, disrupting YAP-TEAD association, suppressing TEAD transcriptional activity, and inhibiting cell growth of Hippo signaling defective malignant pleural mesothelioma (MPM)
Reference:
https://www.biorxiv.org/content/10.1101/2022.05.10.491316v1.full.pdf
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