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PCLAF degrader AD4

 

CAS: 2918262-09-4

 

Chemical Name: 8-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-N,N-bis(2-(((3R,6R,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)ethyl)octanamide

 

 
GLXC-27676For Lab R&D Uses Only
        Cat No: GLXC-27676

 

Purity:               >98% (HPLC)

Storage:             Refrigerator (4 °C)

 

 

Product Description:

Novel potent artemisinin-derived PROTAC (IC50 value of 50.6 nM), effectively degrading PCLAF in RS4;11 cells and activating the p21/Rb axis to exert antitumor activity by directly targeting PCLAF

 

Reference:

https://pubs.acs.org/doi/10.1021/acs.jmedchem.3c00824


Analytical data click for PDF file

 

 

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