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Glixx Laboratorie
CAS: 2918262-09-4
Chemical Name: 8-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-N,N-bis(2-(((3R,6R,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)ethyl)octanamide
Purity: >98% (HPLC)
Novel potent artemisinin-derived PROTAC (IC50 value of 50.6 nM), effectively degrading PCLAF in RS4;11 cells and activating the p21/Rb axis to exert antitumor activity by directly targeting PCLAF
Reference:
https://pubs.acs.org/doi/10.1021/acs.jmedchem.3c00824
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