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Glixx Laboratorie
CAS: 2639775-01-0
Chemical Name: (S)-4-(1-(1-Methyl-3-((3-(trifluoromethyl)phenyl)amino)-1H-indole-2-carboxamido)ethyl)benzoic acid
Purity: >98% (HPLC)
Novel potent and selective EP4 antagonist (hEP4 IC50 = 4.3 nM), inhibiting tumor growth in a CT-26 colon cancer xenograft better than E7046 and its combination with capecitabine significantly suppressing tumor growth (TGI up to 94.26%) in mouse models
Reference:
https://pubs.acs.org/doi/10.1021/acsmedchemlett.2c00495
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