Glixx Laboratories Inc
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Glixx Laboratorie
CAS: 1800487-55-1
Chemical Name: N-(3-(1H-Pyrazol-4-yl)propyl)-3-((4-fluorophenyl)ethynyl)-4-(pyridin-4-yl)benzamide
Purity: >98% (HPLC)
Novel nicotinamide phosphoribosyltransferase (NAMPT) inhibitor, exerting its antileukemic action by depleting NAD+ and ATP, inhibiting the NAD+-requiring DNA damage repair enzyme PARP-1, increasing mitochondrial ROS levels and inducing DNA damage, culminating in apoptosis induction
Ref: https://www.nature.com/articles/s41375-019-0692-5
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