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CAS: 790224-37-2

 

Chemical Name: (2S,3R,4S,5R)-2-(((2S,3R,4S,5S)-3-Acetoxy-2-(((3S,8R,9S,10R,13S,14S,16S,17S)-17-((S)-1-(dodecyloxy)-1-oxopropan-2-yl)-3,17-dihydroxy-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-16-yl)oxy)-5-hydroxytetrahydro-2H-pyran-4-yl)oxy)-4,5-dihydroxytetrahydro-2H-pyran-3-yl 4-methoxybenzoate

 

 
GLXC-21462For Lab R&D Uses Only
        Cat No: GLXC-21462

 

Purity:               >98% (HPLC)

Storage:             Refrigerator (4 °C)

 

 

Product Description:

Novel blocker of the interaction between Bcr-Abl and PTB1B, overcoming imatinib-resistance of chronic myeloid leukemia cells, inhibiting the activation of the IGF-1-PNCA pathway, as demonstrated by decreased expression of IGF-1 (insulin-like growth factor 1), proliferating cell nuclear antigen (PCNA), and its downstream Bcl-2 protein

 

References:

1) https://link.springer.com/article/10.1007%2Fs10637-020-01050-w

2) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6925477/

3) https://onlinelibrary.wiley.com/doi/abs/10.1002/anie.200454237

 

Analytical data click for PDF file

 

 

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