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CAS: N/A
Chemical Name: (4bS,7S,8aR)-7-Hydroxy-3-methoxy-N-(4-methoxyphenyl)-4b,8,8-trimethyl-4b,5,6,7,8,8a,9,10-octahydrophenanthrene-2-carboxamide
Purity: >98% (HPLC)
Novel specific androgen receptor N-terminal domain (AR-NTD) antagonist, binding to AR-NTD directly, blocking the transactivation of AR-NTD and interactions between co-regulatory proteins and androgen response elements (AREs), inhibiting the expression of genes downstream of AR and prostate cancer growth in vitro and in vivo
References:
https://www.mdpi.com/1420-3049/28/12/4743
https://link.springer.com/article/10.1007/s10565-020-09511-x
Analytical data
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