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CAS: 2632305-17-8
Chemical Name: 2-Chloro-4-((3S)-8-(4-(4-(1-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)azetidin-3-yl)piperazine-1-carbonyl)phenyl)-3-methyl-2,8-diazaspiro[4.5]decan-2-yl)benzonitrile
Purity: >98% (HPLC)
Novel potent and orally efficacious proteolysis targeting chimera (PROTAC) degrader of androgen receptor, achieving DC50 values of 0.6 nM and Dmax >90% in inducing AR protein degradation in both the LNCaP and VCaP prostate cancer cell lines, potently and effectively suppressing AR-regulated genes, and inhibiting cancer cell growth
Reference:
https://pubs.acs.org/doi/10.1021/acs.jmedchem.3c00405
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