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ARD-2051

 

CAS: 2632305-17-8

 

Chemical Name: 2-Chloro-4-((3S)-8-(4-(4-(1-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)azetidin-3-yl)piperazine-1-carbonyl)phenyl)-3-methyl-2,8-diazaspiro[4.5]decan-2-yl)benzonitrile

 

 
GLXC-27543For Lab R&D Uses Only
        Cat No: GLXC-27543

 

Purity:               >98% (HPLC)

Storage:             Refrigerator (4 °C)

 

 

Product Description:

Novel potent and orally efficacious proteolysis targeting chimera (PROTAC) degrader of androgen receptor, achieving DC50 values of 0.6 nM and Dmax >90% in inducing AR protein degradation in both the LNCaP and VCaP prostate cancer cell lines, potently and effectively suppressing AR-regulated genes, and inhibiting cancer cell growth

 

Reference:

https://pubs.acs.org/doi/10.1021/acs.jmedchem.3c00405


Analytical data click for PDF file

 

 

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