Glixx Laboratories Inc
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Glixx Laboratorie
CAS: 2603528-97-6
Chemical Name: (2S,3R)-1-(3-Cyano-6-methyl-4-(trifluoromethyl)pyridin-2-yl)-3-hydroxy-N-methyl-N-(m-tolyl)pyrrolidine-2-carboxamide
Purity: >98% (HPLC)
Novel potent, selective, and allosteric inhibitor of the polymerase function of DNA polymerase Polθ, inhibiting the major Polθ-mediated DNA repair process, Theta-Mediated End Joining, without targeting Non-Homologous End Joining, eliciting DNA damage and synthetic lethality in BRCA1- or BRCA2-mutant tumour cells and enhancing the effects of a PARP inhibitor
Ref: https://www.nature.com/articles/s41467-021-23463-8
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