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CAS: N/A
Chemical Name: 8-Chloro-3-(prop-2-yn-1-yl)imidazo[5,1-d][1,2,3,5]tetrazin-4(3H)-one
Purity: >98% (HPLC)
Novel anti-Glioblastoma (anti-GBM) agent, exhibiting activity against cancer cells irrespective of MGMT expression and MMR status, having greater blood-brain barrier penetrance and comparable hematological toxicity relative to TMZ (GLXC-02560), while also matching its maximum tolerated dose in mice when dosed once-per-day over five days
Ref: https://pubs.acs.org/doi/abs/10.1021/acschembio.2c00022
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