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FLT3 inhibitor 34f

 

CAS: N/A

 

Chemical Name: N6-((1r,4r)-4-Aminocyclohexyl)-3-phenyl-N8-(4-(pyrrolidin-1-ylsulfonyl)phenyl)imidazo[1,2-b]pyridazine-6,8-diamine

 

 
GLXC-27656For Lab R&D Uses Only
        Cat No: GLXC-27656

 

Purity:               >98% (HPLC)

Storage:             Refrigerator (4 °C)

 

 

Product Description:

Novel potent FLT3 inhibitor, showing nanomolar inhibitory activity against recombinant FLT3-ITD and FLT3-D835Y (IC50 values 4 and 1 nM, respectively) as well as in the FLT3-ITD-positive AML cell lines MV4-11, MOLM-13, and MOLM-13 expressing the FLT3-ITD-D835Y mutant (GI50 values of 7, 9, and 4 nM, respectively), blocking tumor growth without any adverse effects

 

Reference:

https://pubs.acs.org/doi/10.1021/acs.jmedchem.3c00575


Analytical data click for PDF file

 

 

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