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TSHR-NAM-S37a

 

CAS: 2143452-20-2

 

Chemical Name: S37a; (4aS,5S,5aR,8aR,9R,9aS,10R)-7,10-Diphenyl-3,4a,5,5a,8a,9,9a,10-octahydro-5,9-methanothiazolo[5',4':5,6]thiopyrano[2,3-f]isoindole-2,6,8(7H)-trione

 

 
GLXC-21457For Lab R&D Uses Only
        Cat No: GLXC-21457

 

Purity:               >98% (HPLC)

Storage:             Refrigerator (4 °C)

 

 

Product Description:

Novel highly selective negative allosteric modulator (NAM) of thyrotropin receptor (TSHR), binding at the ectodomain/TMD interface, between the converging helix, ECL1 and the IA, noncompetitively inhibiting PAM-C2-activation

 

References:

https://molpharm.aspetjournals.org/content/96/4/452.long

https://www.liebertpub.com/doi/10.1089/thy.2018.0349

 

Analytical data click for PDF file

 

 

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