Cat No: GLXC-09605

Purity:               > 98% (HPLC)

Storage:             Refrigerator (4 °C)

Product Description:

Npvel potent JAK3-selective inhibitor, selectively targeting garmma-c cytokine pathways while preserving JAK1-dependent anti-inflammatory signaling such as the IL-10 suppressive functions following LPS treatment in macrophages and the suppression of TNFa and IL-1ß production in IL-27-primed macrophages

References:

1) https://onlinelibrary.wiley.com/doi/10.1002/art.41316

2) https://pubs.acs.org/doi/10.1021/acschembio.9b00188

3) https://www.nature.com/articles/mi201738

Analytical data

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