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CAS: N/A
Chemical Name: SAMHD1-IN-5a; ((2R,3S,5R)-5-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-3-hydroxytetrahydrofuran-2-yl)methyl (3-(3'-bromo-[1,1'-biphenyl]-3-carboxamido)propyl) hydrogen phosphate DIPEA salt
For Lab R&D Uses Only
Purity: >98% (HPLC)
Novel competitive inhibitor of SAMHD1 dNTPase activity against GTP binding to the A1 site, inducing inactive dimers that are deficient in tetramerization, preventing ssDNA and ssRNA binding
Reference:
https://pubs.acs.org/doi/10.1021/acschembio.3c00118
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