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Glixx Laboratorie
CAS: 1905481-40-4
Chemical Name: (R)-1-Cyclopropyl-3-(1-(3-isopropyl-1H-pyrazole-5-carbonyl)pyrrolidin-3-yl)urea
Purity: >98% (HPLC)
Novel highly potent KDM5B inhibitor (IC50 = 0.044 μM), reducing Ang II-induced activation of cardiac fibroblasts in vitro, exhibiting good PK profile (F = 42.37%), and reducing isoprenaline-induced myocardial remodeling and fibrosis in vivo
Ref: https://pubs.acs.org/doi/10.1021/acs.jmedchem.2c00797
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